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| Nomenclature |
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Symbol:
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Dhhtm1Amc
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Name:
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desert hedgehog;
targeted mutation 1, Andrew P McMahon
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MGI ID: |
MGI:1934259 |
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Synonyms: |
Dhh- |
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Gene:
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Dhh
Location:
Chr15:98893031-98898540 bp, - strand
Genetic Position: Chr15,
55.05 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:57914
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Parent Cell Line:
| CJ7 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 1, 2 and part of 3 were replaced with a neomycin cassette. The deleted segments encode a conserved polypeptide required for protein function. Thus, no functional protein is predicted to be produced from this allele. (J:57914)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:57914
Bitgood MJ et al.,
"Sertoli cell signaling by Desert hedgehog regulates the male germline."
Curr Biol 1996 Mar 1;6(3):298-304
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All: |
12 reference(s)
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Analysis Tools
