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| Nomenclature |
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Symbol:
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Ihhtm1Amc
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Name:
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Indian hedgehog;
targeted mutation 1, Andrew P McMahon
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MGI ID: |
MGI:1934258 |
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Synonyms: |
Ihh-, Ihhn |
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Gene:
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Ihh
Location:
Chr1:74945319-74951651 bp, - strand
Genetic Position: Chr1,
38.55 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:57297
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced the entire first exon, which encodes much of the signaling peptide, and approximately 1kb of flanking sequence. (J:57297)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Hirschsprung disease in homozygous mice (J:62158)
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| References |
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Original: |
J:57297
St-Jacques B et al.,
"Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation [published erratum appears in Genes Dev 1999 Oct 1;13(19):2617]"
Genes Dev 1999 Aug 15;13(16):2072-86
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All: |
34 reference(s)
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Analysis Tools
