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| Nomenclature |
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Symbol:
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Soat1tm1Ishi
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Name:
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sterol O-acyltransferase 1;
targeted mutation 1, Shun Ishibashi
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MGI ID: |
MGI:1934032 |
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Synonyms: |
ACAT-1 |
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Gene:
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Soat1
Location:
Chr1:156428108-156474328 bp, - strand
Genetic Position: Chr1,
67.71 cM
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Narrow eye fissures and atrophic meibomian glands in Soat1tm1Ishi/Soat1tm1Ishi mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:63468
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Parent Cell Line:
| JH1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced 4 kb of sequence encoding the first transmembrane domain and a conserved serine. Northern blot analyses of homozygous mutant mice did not detect any transcripts in macrophages, adrenal glands, ovaries and testes. Western blot analyses of macrophages, adrenal glands, ovaries, and testes did not detect the protein in homozygous mutant mice. (J:63468)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Soat1 Mutation:
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10 strains or lines available |
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| References |
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Original: |
J:63468
Yagyu H et al.,
"Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia."
J Biol Chem 2000 Jul 14;275(28):21324-30
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All: |
1 reference(s)
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Analysis Tools
