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| Nomenclature |
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Symbol:
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Bmp7tm1Kry
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Name:
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bone morphogenetic protein 7;
targeted mutation 1, Gerard Karsenty
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MGI ID: |
MGI:1934010 |
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Synonyms: |
Bmp7-, Bmp7delta, bmp-7m1 |
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Gene:
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Bmp7
Location:
Chr2:172868012-172940321 bp, - strand
Genetic Position: Chr2,
95.54 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:30056
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Parent Cell Line:
| AB2.1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: An hypoxanthine phosphoribosyl transferase (hprt) minigene replaced a genomic fragment containing exons 6 and 7. These sequences encode the mature domain of the processed polypeptide. Northern blot analysis revealed that no stable transcript was produced from this allele in homozygous mice. (J:30056)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:30056
Luo G et al.,
"BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning."
Genes Dev 1995 Nov 15;9(22):2808-20
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All: |
12 reference(s)
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Analysis Tools
