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| Nomenclature |
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Symbol:
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Cln3tm1Nbm
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Name:
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ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease);
targeted mutation 1, Robert L Nussbaum
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MGI ID: |
MGI:1933976 |
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Synonyms: |
Cln3- |
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Gene:
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Cln3
Location:
Chr7:126571207-126585817 bp, - strand
Genetic Position: Chr7,
69.16 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:58230
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 2-6 and most of exon 1, including the start codon of the Cln3 gene were replaced with a neomycin resistance gene transcribed in the reverse orientation from a mouse PGK promoter. (J:55232, J:58230)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:58230
Mitchison HM et al.,
"Targeted disruption of the Cln3 gene provides a mouse model for Batten disease."
Neurobiol Dis 1999 Oct;6(5):321-34
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All: |
27 reference(s)
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Analysis Tools
