|
|
| Nomenclature |
|
Symbol:
|
Cdkn2ctm1Bbd
|
|
Name:
|
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4);
targeted mutation 1, Mariano Barbacid
|
|
MGI ID: |
MGI:1933761 |
|
Synonyms: |
Ink4c-, p18INK4c- |
|
Gene:
|
Cdkn2c
Location:
Chr4:109660876-109667189 bp, - strand
Genetic Position: Chr4,
51.32 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:63299
|
|
Parent Cell Line:
| CJ7 (ES Cell) |
|
Strain of Origin:
|
129S1/Sv-Oca2+ Tyr+ Kitl+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: Exon 2, encoding amino acid residues 43-168, was replaced by a neomycin cassette. No protein was detected in Western blots of lysates derived from tissues of 3 month old homozygous mutant mice. (J:63299)
|
|
Inheritance: | |
Recessive |
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Cdkn2c Mutation:
|
3 strains or lines available |
|
| References |
|
Original: |
J:63299
Latres E et al.,
"Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis"
EMBO J 2000 Jul 3;19(13):3496-506
|
|
All: |
17 reference(s)
|
|
Analysis Tools
