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| Nomenclature |
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Symbol:
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Cdkn1ctm1Bbd
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Name:
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cyclin-dependent kinase inhibitor 1C (P57);
targeted mutation 1, Mariano Barbacid
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MGI ID: |
MGI:1933757 |
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Synonyms: |
p57kip2 (-) |
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Gene:
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Cdkn1c
Location:
Chr7:143458350-143461050 bp, - strand
Genetic Position: Chr7,
88.22 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:40142
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: Deletion of 1.1 kb of genomic sequence that includes the first exon and half the second exon, encoding amino acid residues 1-181 of the protein. No protein was detected in Western blots of lysates of primary embryo fibroblasts derived from homozygous mutant mice. (J:40142)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cdkn1c Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:40142
Yan Y et al.,
"Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development."
Genes Dev 1997 Apr 15;11(8):973-83
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All: |
3 reference(s)
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Analysis Tools
