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| Nomenclature |
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Symbol:
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Cdkn1atm1Tyj
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Name:
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cyclin-dependent kinase inhibitor 1A (P21);
targeted mutation 1, Tyler Jacks
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MGI ID: |
MGI:1933751 |
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Synonyms: |
Cdkn1a-, p21-, p21cip- |
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Gene:
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Cdkn1a
Location:
Chr17:29090979-29100722 bp, + strand
Genetic Position: Chr17,
15.12 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:68068
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The coding sequences were replaced by a neomycin cassette. No protein was detected by immunoprecipitation of ES cell lysates in which both alleles were disrupted. (J:68068)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:68068
Brugarolas J et al.,
"Radiation-induced cell cycle arrest compromised by p21 deficiency."
Nature 1995 Oct 12;377(6549):552-7
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All: |
115 reference(s)
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Analysis Tools
