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| Nomenclature |
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Symbol:
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Notch2tm1Grid
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Name:
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notch 2;
targeted mutation 1, Tom Gridley
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MGI ID: |
MGI:1933205 |
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Synonyms: |
Notch2-, Notch2del1 |
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Gene:
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Notch2
Location:
Chr3:98013538-98150367 bp, + strand
Genetic Position: Chr3,
42.42 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:67157
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Parent Cell Line:
| CJ7 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: This is a hypomorphic allele. A neomycin resistance cassette replaced 0.4 kb of sequence, including part of the exon encoding EGF repeat 14, the splice donor site at the 3' end of this exon, and 0.3 kb of intron. mRNA species are detected in homozygous mutant embryos that appear to be the result of inframe splicing around the neomycin cassette. Proteins derived from these transcripts are predicted to have a deletion of one or two EGF repeats. (J:67157)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:67157
McCright B et al.,
"Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation."
Development 2001 Feb;128(4):491-502
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All: |
8 reference(s)
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Analysis Tools
