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| Nomenclature |
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Symbol:
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Ttpatm1Far
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Name:
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tocopherol (alpha) transfer protein;
targeted mutation 1, Bob Farese
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MGI ID: |
MGI:1932559 |
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Synonyms: |
alpha-TTP-KO, Ttpa- |
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Gene:
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Ttpa
Location:
Chr4:20007938-20030785 bp, + strand
Genetic Position: Chr4,
7.76 cM, cytoband A3
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Morphology of aortic lesions in Apoetm1Unc/Apoetm1Unc and Apoetm1Unc/Apoetm1Unc Ttpatm1Far/Ttpatm1Far mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:66419
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Parent Cell Line:
| RF8 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A lacZ-neomycin resistance cassette replaced part of the 5' untranslated region and exon 1 including the translational start codon. Immunoblot analysis of liver did not detect wild-type protein in homozygous mutant mice. (J:66419)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:66419
Terasawa Y et al.,
"Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E"
Proc Natl Acad Sci U S A 2000 Dec 5;97(25):13830-4
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All: |
6 reference(s)
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Analysis Tools
