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| Nomenclature |
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Symbol:
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F9tm1Ver
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Name:
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coagulation factor IX;
targeted mutation 1, Inder M Verma
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MGI ID: |
MGI:1932265 |
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Synonyms: |
FIX (-) |
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Gene:
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F9
Location:
ChrX:59999464-60030759 bp, + strand
Genetic Position: ChrX,
33.5 cM, cytoband A6-A7
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Bleeding disorder of F9tm1Ver/F9tm1Ver mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:43590
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Replacement of the last exon, encoding a large portion of the catalytic domain, with a neomycin cassette. mRNA was not detected in mutant mouse liver as assayed by Northern blot analysis, and no protein could be detected by Western blot analysis of plasma. (J:43590)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any F9 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:43590
Wang L et al.,
"A factor IX-deficient mouse model for hemophilia B gene therapy."
Proc Natl Acad Sci U S A 1997 Oct 14;94(21):11563-6
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All: |
3 reference(s)
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Analysis Tools
