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| Nomenclature |
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Symbol:
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Spp1tm1Rit
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Name:
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secreted phosphoprotein 1;
targeted mutation 1, Susan R Rittling
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MGI ID: |
MGI:1932084 |
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Synonyms: |
Eta-1-, Opn- |
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Gene:
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Spp1
Location:
Chr5:104435118-104441050 bp, + strand
Genetic Position: Chr5,
50.68 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:56535
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Parent Cell Line:
| AB2.1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: Insertion of a neomycin resistance cassette into exon 6 immediately 5' of the RGD sequence disrupted the Spp1 gene. Northern analysis of homozygous mutant kidney detected low levels of a high molecular weight RNA species, but no wild-type or truncated Spp1 transcript. Immunoblot analysis detected low levels of a truncated form of the protein in bone but not in other tissues, fluids, or cells of homozygous mutant mice. (J:56535)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:56535
Rittling SR et al.,
"Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro."
J Bone Miner Res 1998 Jul;13(7):1101-11
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All: |
69 reference(s)
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Analysis Tools
