|
|
| Nomenclature |
|
Symbol:
|
Spp1tm1Blh
|
|
Name:
|
secreted phosphoprotein 1;
targeted mutation 1, Brigid L Hogan
|
|
MGI ID: |
MGI:1932083 |
|
Synonyms: |
eta1, Eta-1, Opn-, OPN-, OPN-KO |
|
Gene:
|
Spp1
Location:
Chr5:104435118-104441050 bp, + strand
Genetic Position: Chr5,
50.68 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:46863
|
|
Parent Cell Line:
| TL1/TL-1 (ES Cell) |
|
Strain of Origin:
|
129S6/SvEvTac
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: A PGK neomycin resistance cassette replaced exons 4-7 of the Spp1 gene. No Spp1 transcript was detected by RT-PCR in embryonic fibroblasts or adult kidney from homozygous mutant animals. Spp1 transcript was not detected in homozygous mutant animals by in situ hybridization. Immunohistochemistry studies of adult kidney and bone did not detect protein in homozygous mutant mice. (J:46863)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:46863
Liaw L et al.,
"Altered wound healing in mice lacking a functional osteopontin gene (spp1)."
J Clin Invest 1998 Apr 1;101(7):1468-78
|
|
All: |
58 reference(s)
|
|
Analysis Tools
