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| Nomenclature |
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Symbol:
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Slc1a3tm1Kta
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Name:
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solute carrier family 1 (glial high affinity glutamate transporter), member 3;
targeted mutation 1, Kohichi Tanaka
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MGI ID: |
MGI:1931872 |
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Synonyms: |
GLAST-, GLAST KO |
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Gene:
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Slc1a3
Location:
Chr15:8634124-8710764 bp, - strand
Genetic Position: Chr15,
3.82 cM, cytoband A2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:46746
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK-neomycin resistance cassette replaced sequences in exon 6 that code for the fourth transmembrane segment of the protein. Cerebellar transcript was not detected in homozygous mutant animals. Immunoblot analysis of cerebellar membranes did not detect protein in homozygous mutant mice. (J:46746)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Slc1a3 Mutation:
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22 strains or lines available |
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| References |
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Original: |
J:46746
Watase K et al.,
"Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice."
Eur J Neurosci 1998 Mar;10(3):976-88
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All: |
25 reference(s)
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Analysis Tools
