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| Nomenclature |
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Symbol:
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Gpr143tm1Inc
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Name:
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G protein-coupled receptor 143;
targeted mutation 1, Barbara Incerti
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MGI ID: |
MGI:1931862 |
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Synonyms: |
Oa1- |
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Gene:
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Gpr143
Location:
ChrX:152781921-152808646 bp, + strand
Genetic Position: ChrX,
68.46 cM, cytoband F2-F3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:66139
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Parent Cell Line:
| AB2.2 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK-hprt expression cassette replaced exon 1 including the start codon of the gene. Several human mutations are located in the corresponding human exon 1. Northern analysis of primary melanocyte cultures did not detect transcript in homozygous mutant neonates. (J:66139)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gpr143 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:66139
Incerti B et al.,
"Oa1 knock-out: new insights on the pathogenesis of ocular albinism type 1"
Hum Mol Genet 2000 Nov 22;9(19):2781-8
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All: |
6 reference(s)
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Analysis Tools
