|
|
| Nomenclature |
|
Symbol:
|
Kcnq1tm1Apf
|
|
Name:
|
potassium voltage-gated channel, subfamily Q, member 1;
targeted mutation 1, Andrew P Feinberg
|
|
MGI ID: |
MGI:1931858 |
|
Synonyms: |
Kvlqt1- |
|
Gene:
|
Kcnq1
Location:
Chr7:143107254-143427042 bp, + strand
Genetic Position: Chr7,
88.12 cM
|
|
Cochlear abnormalities in Kcnq1tm1Apf/Kcnq1tm1Apf mice
Show the 3 image(s) involving this allele.
|
 |
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:66428
|
|
Parent Cell Line:
| E14 (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: Insertion of a neomycin resistance cassette into exon 1 disrupted the gene. The authors predict that all isoforms of the protein would be inactivated in homozygous mutant animals. RT-PCR did not detect expression of the tanscript in tissues of homozygous mice. (J:66428)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Kcnq1 Mutation:
|
11 strains or lines available |
|
| References |
|
Original: |
J:66428
Lee MP et al.,
"Targeted disruption of the kvlqt1 gene causes deafness and gastric hyperplasia in mice"
J Clin Invest 2000 Dec;106(12):1447-55
|
|
All: |
3 reference(s)
|
|
Analysis Tools
