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| Nomenclature |
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Symbol:
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Crkltm1Imo
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Name:
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v-crk sarcoma virus CT10 oncogene homolog (avian)-like;
targeted mutation 1, Akira Imamoto
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MGI ID: |
MGI:1931805 |
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Synonyms: |
Crkol - |
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Gene:
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Crkl
Location:
Chr16:17451987-17486255 bp, + strand
Genetic Position: Chr16,
10.82 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:67826
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Parent Cell Line:
| AK7 (ES Cell) |
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Strain of Origin:
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129S4/SvJaeSor
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A loxP flanked neo cassette was inserted in the first coding exon. Western blot analysis confirmed that no protein was expressed in homozygous mutant embryos. (J:67826)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Crkl Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:67826
Guris DL et al.,
"Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome."
Nat Genet 2001 Mar;27(3):293-8
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All: |
5 reference(s)
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Analysis Tools
