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| Nomenclature |
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Symbol:
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Fgfr3tm1Dor
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Name:
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fibroblast growth factor receptor 3;
targeted mutation 1, David M Ornitz
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MGI ID: |
MGI:1931521 |
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Synonyms: |
Fgfr3 - |
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Gene:
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Fgfr3
Location:
Chr5:33721724-33737067 bp, + strand
Genetic Position: Chr5,
17.83 cM, cytoband B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:32991
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Parent Cell Line:
| SM1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin cassette replaced 3 kb of sequence that encodes the Ig-like domain II through the transmembrane domain. RNAase protection analysis on samples derived from homozygous mutant adult brain indicates that this allele produces an aberrant transcript. However, any translation product produced would be unable to bind ligand and is predicted not to be transported to the cell surface. (J:32991)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:32991
Colvin JS et al.,
"Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3."
Nat Genet 1996 Apr;12(4):390-7
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All: |
24 reference(s)
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Analysis Tools
