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| Nomenclature |
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Symbol:
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Nr3c1tm2Gsc
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Name:
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nuclear receptor subfamily 3, group C, member 1;
targeted mutation 2, Gunther Schutz
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MGI ID: |
MGI:1931327 |
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Synonyms: |
GR-, GRflox, Grl1loxP, Grl1tm2Gsc, GRlox, GRloxP |
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Gene:
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Nr3c1
Location:
Chr18:39410545-39491301 bp, - strand
Genetic Position: Chr18,
21.09 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:57315
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: Insertion of loxP sites flanking exon 3. A loxP flanked neomycin/thymidine kinase cassette in intron 3 was removed by transient expression of Cre recombinase in ES cells prior to blastocyst injection. (J:57315)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:57315
Tronche F et al.,
"Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety."
Nat Genet 1999 Sep;23(1):99-103
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All: |
40 reference(s)
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Analysis Tools
