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| Nomenclature |
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Symbol:
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Cd19tm1(cre)Cgn
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Name:
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CD19 antigen;
targeted mutation 1, University of Cologne
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MGI ID: |
MGI:1931143 |
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Synonyms: |
B-Cre, CD19-, Cd19cre, Cd19Cre, CD19-Cre, CD19-KO |
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Gene:
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Cd19
Location:
Chr7:126408450-126414870 bp, - strand
Genetic Position: Chr7,
69.01 cM, cytoband F3-F4
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:27463
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: In frame insertion of a cre recombinase gene into the first coding exon followed by an frt-flanked neomycin cassette. A frameshift mutation was also introduced into exon 5. This allele expresses cre recombinase specifically in B lineage cells throughout development. (J:27463)
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Recombinase activity
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Activity in:
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hemolymphoid system
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Not detected in:
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alimentary system,
cardiovascular system,
embryo-other,
extraembryonic component,
integumental system,
liver & biliary system,
muscle,
nervous system,
postnatal-other,
renal & urinary system,
reproductive system,
respiratory system
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Driver:
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Cd19
Summary of all recombinase alleles
driven by Cd19.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:27463
Rickert RC et al.,
"Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice."
Nature 1995 Jul 27;376(6538):352-5
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All: |
252 reference(s)
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Analysis Tools
