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| Nomenclature |
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Symbol:
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Vegfatm1Pec
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Name:
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vascular endothelial growth factor A;
targeted mutation 1, Peter Carmeliet
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MGI ID: |
MGI:1931047 |
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Synonyms: |
VEGF120 |
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Gene:
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Vegfa
Location:
Chr17:46016993-46032369 bp, - strand
Genetic Position: Chr17,
22.79 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:56003
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Replacement of exons 6 and 7 with a lox-P flanked neomycin cassette. The neomycin cassette was removed prior to blastocyst injection by Cre-mediated recombination in ES cells, resulting in the final allele. A highly soluble isoform of the encoded protein is expressed from this allele. (J:56003)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:56003
Carmeliet P et al.,
"Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 [see comments]"
Nat Med 1999 May;5(5):495-502
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All: |
20 reference(s)
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Analysis Tools
