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| Nomenclature |
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Symbol:
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Rb1tm2Brn
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Name:
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retinoblastoma 1;
targeted mutation 2, Anton Berns
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MGI ID: |
MGI:1931018 |
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Synonyms: |
flox19-RB1, pRbL2, pRblox, Rbf, RbF19, Rblox, RbLoxP |
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Gene:
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Rb1
Location:
Chr14:73183673-73325822 bp, - strand
Genetic Position: Chr14,
38.73 cM, cytoband D3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:61961
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: LoxP sites flanking exon 19 were introduced to the gene by homologous recombination. The targeted allele was verified by Southern blot analysis. (J:61961)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Animals homozygous for the conditional floxed exon 19 allele did not show any tumor predisposition phenotype, and were of normal fertility.
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| References |
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Original: |
J:61961
Marino S et al.,
"Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum."
Genes Dev 2000 Apr 15;14(8):994-1004
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All: |
108 reference(s)
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Analysis Tools
