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| Nomenclature |
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Symbol:
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Psen1tm1Pcw
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Name:
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presenilin 1;
targeted mutation 1, Philip C Wong
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MGI ID: |
MGI:1930934 |
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Synonyms: |
PS1- |
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Gene:
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Psen1
Location:
Chr12:83688563-83735199 bp, + strand
Genetic Position: Chr12,
38.84 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:40308
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Parent Cell Line:
| AB2.1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced 1.9kb of sequence containing the second coding exon. Immunoblot analysis using antibodies specific for epitopes contained within each of the endoproteolytic products of the gene did not detect protein in SDS extracts of homozygous mutant E18.5 embryos. (J:40308)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Psen1 Mutation:
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20 strains or lines available |
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| References |
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Original: |
J:40308
Wong PC et al.,
"Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm."
Nature 1997 May 15;387(6630):288-92
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All: |
27 reference(s)
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Analysis Tools
