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| Nomenclature |
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Symbol:
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Brca1tm1Arge
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Name:
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breast cancer 1;
targeted mutation 1, Argiris Efstratiadis
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MGI ID: |
MGI:1930613 |
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Synonyms: |
Brca1ex2, Brca1KO |
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Gene:
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Brca1
Location:
Chr11:101488764-101551955 bp, - strand
Genetic Position: Chr11,
65.18 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:40594
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Parent Cell Line:
| CCE/EK.CCE (ES Cell) |
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Strain of Origin:
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129S/SvEv-Gpi1c
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Replacement of exon 2, encoding part of the RING finger motif, and part of the flanking introns with a neomycin cassette. (J:40594)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Brca1 Mutation:
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42 strains or lines available |
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| References |
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Original: |
J:40594
Ludwig T et al.,
"Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos."
Genes Dev 1997 May 15;11(10):1226-41
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All: |
6 reference(s)
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Analysis Tools
