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| Nomenclature |
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Symbol:
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Erbb2tm1Cbm
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Name:
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v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian);
targeted mutation 1, Carmen Birchmeier
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MGI ID: |
MGI:1929071 |
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Synonyms: |
erbB2- |
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Gene:
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Erbb2
Location:
Chr11:98412470-98437716 bp, + strand
Genetic Position: Chr11,
61.75 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:48515
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: Fusion of lacZ sequences to an exon encoding the cytoplasmic juxtamembrane domain. This allele expresses a fusion protein of ErbB2 and beta-galactosidase that lacks the kinase domain of ErbB2. (J:48515)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Erbb2 Mutation:
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8 strains or lines available |
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Notes |
Phenotypic Similarity to Human Syndrome: Dilated Cardiomyopathy in mice with conditional deletion in cardiomyocytes (J:77347)
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| References |
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Original: |
J:48515
Britsch S et al.,
"The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system."
Genes Dev 1998 Jun 15;12(12):1825-36
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All: |
6 reference(s)
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Analysis Tools
