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| Nomenclature |
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Symbol:
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Emx1tm1(cre)Ito
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Name:
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empty spiracles homeobox 1;
targeted mutation 1, Shigeyoshi Itohara
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MGI ID: |
MGI:1928281 |
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Synonyms: |
Emx1Cre, (Emx1)Cre, Emx1Cre, Emx1-Cre, Emx1tm1(cre)Rik |
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Gene:
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Emx1
Location:
Chr6:85187438-85204462 bp, + strand
Genetic Position: Chr6,
37.21 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:64064
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A cDNA encoding cre recombinase with an N-terminal nuclear localization signal (nls) was inserted immediately before the translation initiation codon in the gene. Under the control of this promoter, Cre activity is detected by embryonic day 12.5; Cre mediated recombination was observed in dorsal telencephalon, neocortex, hippocampus, and olfactory bulb. An Frt flanked Neo cassette was retained in this allele (J:64064)
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Recombinase activity
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:64064
Iwasato T et al.,
"Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex."
Nature 2000 Aug 17;406(6797):726-31
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All: |
44 reference(s)
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Analysis Tools
