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| Nomenclature |
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Symbol:
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Grin1tm1Bhk
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Name:
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glutamate receptor, ionotropic, NMDA1 (zeta 1);
targeted mutation 1, Beverly H Koller
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MGI ID: |
MGI:1928280 |
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Synonyms: |
GluN1Rneo, NR1-, Nr1neo, Nr1neo- |
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Gene:
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Grin1
Location:
Chr2:25291181-25319187 bp, - strand
Genetic Position: Chr2,
17.14 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:57125
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (other) |
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Mutation: | |
Insertion |
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Mutation details: Hypomorphic allele. Insertion of a neomycin cassette into intron 20 of the gene reduces expression to ~5-10% of normal levels. (J:57125)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Grin1 Mutation:
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10 strains or lines available |
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| References |
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Original: |
J:57125
Mohn AR et al.,
"Mice with reduced NMDA receptor expression display behaviors related to schizophrenia."
Cell 1999 Aug 20;98(4):427-36
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All: |
11 reference(s)
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Analysis Tools
