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| Nomenclature |
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Symbol:
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Casp1tm1Sesh
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Name:
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caspase 1;
targeted mutation 1, Tara Seshadri
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MGI ID: |
MGI:1927822 |
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Synonyms: |
casp-1-, Casp1 -, Casp1-/Casp11129mt, Caspase-1-, ICE - |
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Gene:
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Casp1
Location:
Chr9:5298517-5307265 bp, + strand
Genetic Position: Chr9,
2.46 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:22964
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin expression cassette was inserted into exon 6, deleting 31 bp of sequence encoding the region of the active site and rendering the sequence out of frame after the insertion. Northern blot analysis on spleen RNA demonstrated an absence of the normal transcript in homozygous mice, and western blot analysis showed that the protein was not expressed in peritoneal macrophages of homozygous mice. This allele was generated in ES cells that lack protein expression of Casp11 (Casp129mt). (J:22964)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
The ES cells used to generate this allele contain the linked Casp4del truncated allele that fails to produce a functional Casp4. Phenotypes associated with this allele may be affected by the presence of the Caspdel allele. J:193522
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| References |
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Original: |
J:22964
Li P et al.,
"Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock."
Cell 1995 Feb 10;80(3):401-11
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All: |
66 reference(s)
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Analysis Tools
