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| Nomenclature |
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Symbol:
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Nf2tm2Gth
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Name:
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neurofibromatosis 2;
targeted mutation 2, Gilles Thomas
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MGI ID: |
MGI:1926955 |
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Synonyms: |
Nf2F, Nf2flox2, Nf2lox |
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Gene:
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Nf2
Location:
Chr11:4765845-4849536 bp, - strand
Genetic Position: Chr11,
3.0 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:63264
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Parent Cell Line:
| HM-1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd-Hprtb-m3
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Insertion of loxP sites flanking exon 2 of the Nf2 gene. No effect on the function of Nf2.
(J:63264)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Renal Cell Carcinoma (Nf2tm2Gth Tg(Vil-cre)20Syr; J:150071)
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| References |
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Original: |
J:63264
Giovannini M et al.,
"Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2."
Genes Dev 2000 Jul 1;14(13):1617-30
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All: |
17 reference(s)
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Analysis Tools
