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| Nomenclature |
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Symbol:
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Cdkn2atm1Cjs
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Name:
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cyclin-dependent kinase inhibitor 2A;
targeted mutation 1, Charles J Scherr
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MGI ID: |
MGI:1926877 |
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Synonyms: |
ARF-, p19Arf-, p19ARF-, p19Arf-null |
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Gene:
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Cdkn2a
Location:
Chr4:89274473-89294653 bp, - strand
Genetic Position: Chr4,
42.15 cM, cytoband C3-C6
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Abnormal retrolental tissue present in the eyes of neonatal Cdkn2atm1Cjs/Cdkn2atm1Cjs mice
Show the 6 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:44427
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Replacement of exon 1 beta of the Cdkn2a gene, encoding the translation start site for alternative splice transcript p19ARF, with a neomycin cassette. Note that expression of alternative splice transcript p16Ink4a, transcribed from exon 1 alpha, is not affected by this mutation. (J:44427)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:44427
Kamijo T et al.,
"Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF."
Cell 1997 Nov 28;91(5):649-59
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All: |
104 reference(s)
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Analysis Tools
