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| Nomenclature |
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Symbol:
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Stat3tm2Aki
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Name:
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signal transducer and activator of transcription 3;
targeted mutation 2, Shizuo Akira
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MGI ID: |
MGI:1926816 |
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Synonyms: |
Stat3flox, Stat3flx, STAT3lox, STAT3-loxP |
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Gene:
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Stat3
Location:
Chr11:100885098-100939540 bp, - strand
Genetic Position: Chr11,
63.82 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:50443
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: Insertion of loxP sites flanking exons encoding the tyrosine phosphorylation site. No phenotypic effect on the function of the Stat3 gene.
(J:50443)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Stat3 Mutation:
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28 strains or lines available |
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| References |
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Original: |
J:50443
Takeda K et al.,
"Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice."
J Immunol 1998 Nov 1;161(9):4652-60
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All: |
128 reference(s)
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Analysis Tools
