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| Nomenclature |
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Symbol:
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Tsc2tm1Tno
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Name:
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tuberous sclerosis 2;
targeted mutation 1, Tetsuo Noda
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MGI ID: |
MGI:1926345 |
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Synonyms: |
Tsc2- |
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Gene:
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Tsc2
Location:
Chr17:24595937-24632629 bp, - strand
Genetic Position: Chr17,
12.41 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:52464
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 3kb genomic fragment that contains part of exon 2, all of exons 3 and 4, and part of exon 5 was replaced by a promoterless NLS-lacZ gene fused in-frame to exon 2, followed by a floxed PGK-neomycin resistance cassette. (J:52464)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tsc2 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:52464
Kobayashi T et al.,
"Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice."
Cancer Res 1999 Mar 15;59(6):1206-11
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All: |
2 reference(s)
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Analysis Tools
