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| Nomenclature |
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Symbol:
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Irf8tm1Hor
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Name:
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interferon regulatory factor 8;
targeted mutation 1, Ivan Horak
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MGI ID: |
MGI:1926332 |
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Synonyms: |
ICSBP-, IRF-8- |
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Gene:
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Irf8
Location:
Chr8:120736358-120756694 bp, + strand
Genetic Position: Chr8,
70.05 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:36038
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A PGK-neomycin gene was inserted into the second exon, disrupting sequences encoding the DNA binding domain. (J:36038)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:36038
Holtschke T et al.,
"Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene."
Cell 1996 Oct 18;87(2):307-17
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All: |
61 reference(s)
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Analysis Tools
