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| Nomenclature |
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Symbol:
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Gt(ROSA)26Sor
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Name:
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gene trap ROSA 26, Philippe Soriano
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MGI ID: |
MGI:1890203 |
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Synonyms: |
gtrosa26, R26R3, R26tg, ROSA26, Rosa26lacZ, ROSA26-lacZ, TgR(ROSA26)26Sor |
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Gene:
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Gt(ROSA)26Sor
Location:
Chr6:113067428-113077333 bp, - strand
Genetic Position: Chr6,
52.73 cM
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Mutation
origin |
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Mutant Cell Line:
| FHCRC-GT-ROSA26 (FHCRC) |
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Germline Transmission:
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Earliest citation of germline transmission:
J:79478
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Parent Cell Line:
| AB1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprt+
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Mutation
description |
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Allele
Type: | |
Gene trapped |
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Mutation: | |
Insertion of gene trap vector Vector: ROSABetageo |
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Mutation details: Random insertion of retroviral gene trap vector ROSA, Reverse Orientation with Splice Acceptor, which contains the beta-galactosidase gene and accompanying splice acceptor and neo sequences. The construct was inserted in reverse orientation in the retroviral vector pGen-. The transgene is controlled by an unknown endogenous promoter. lacZ is expressed in all tissues of the developing embryo and in most tissues of the adult transgenic mouse. (J:39814, J:79478)
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Sequence Tags: |
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Sequence tag details (1 tag)
| Tag ID | GenBank ID | Method |
Tag Location (trapped strand)* | Select |
* GRCm38
(strand of gene trap mutagenesis) |
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Genome Context: |
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Genome Browser view of this mutation
Blue line marks
approximate position of gene trap insertion
185 gene trap insertions have trapped this gene
View all gene trap sequence tags in this region
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Inheritance: | |
Not Specified |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
ES cell line = AB1 or AB2.1. No overt phenotypes in heterozygous or homozygous animals. The trapped gene appears to be ubiquitously expressed during embryonic development and in all hematopoietic cells.
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| References |
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Original: |
J:79478
Friedrich G et al.,
"Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice."
Genes Dev 1991 Sep;5(9):1513-23
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All: |
82 reference(s)
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Analysis Tools
