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| Nomenclature |
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Symbol:
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Klkl
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Name:
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klotho
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MGI ID: |
MGI:1889570 |
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Synonyms: |
alpha-kl-, kl, klothohm |
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Gene:
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Kl
Location:
Chr5:150952607-150993809 bp, + strand
Genetic Position: Chr5,
89.77 cM, cytoband G3
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Transgene
origin |
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Strain of Origin:
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C57BL/6J and C3H/J
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, gene disruption) |
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Mutation: | |
Deletion |
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Mutation details: This allele was discovered after mating and screening mice that did not express an exogenous transgene (rabbit type-I sodium-proton exchanger) in other work. One offspring from these matings showed an interesting phenotype, and the mutant was named klotho. It was determined that insertion of the unrelated, exogenous transgene had caused an 8 kb deletion in the 5' upstream region of the Kl locus in the mutant animal. (J:44109)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Kl Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:44109
Kuro-o M et al.,
"Mutation of the mouse klotho gene leads to a syndrome resembling ageing [see comments]"
Nature 1997 Nov 6;390(6655):45-51
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All: |
61 reference(s)
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Analysis Tools
