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| Nomenclature |
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Symbol:
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Bey
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Name:
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bulgy-eye
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MGI ID: |
MGI:1889298 |
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Gene:
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Bey
Location:
unknown
Genetic Position: Chr7,
Syntenic
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Mutation
origin |
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Strain of Origin:
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129S/SvEv-Oca2+ Tyr+
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Mutation
description |
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Allele
Type: | |
Not Applicable |
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Mutation: | |
Insertion |
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Mutation details: This mutation was induced by retroviral mutagenesis using an 8.0 kb myeloproliferative sarcoma retrovirus MPSV-mos-neo in mouse embryonic stem cells; an additional 154 bp of unique sequence also integrated at the locus during mutagenesis. The insertion site was identified as the intergenic region between Fgf3 and Fgf4. The retrovirus landed in the opposite transcriptional orientation to both genes and is approximately 10 kb downstream of Fgf3 and 5 kb upstream of Fgf4. Ectopic expression of both genes was up-regulated in the cranial suture region in mutant mice. (J:47965)
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Inheritance: | |
Dominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Bey Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:47965
Carlton MB et al.,
"Crouzon-like craniofacial dysmorphology in the mouse is caused by an insertional mutation at the Fgf3/Fgf4 locus."
Dev Dyn 1998 Jun;212(2):242-9
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All: |
1 reference(s)
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Analysis Tools
