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| Nomenclature |
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Symbol:
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LeprTg(Mth11)1Aig
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Name:
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leptin receptor;
transgene insertion 1, Bernhard Aigner
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MGI ID: |
MGI:1888983 |
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Gene:
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Lepr
Location:
Chr4:101717404-101815352 bp, + strand
Genetic Position: Chr4,
46.96 cM
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Transgene
origin |
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Strain of Origin:
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Him:OF1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, gene disruption) |
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Mutation: | |
Intragenic deletion |
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Mutation details: The mutation was caused by insertion of a transgene. The construct contained 2.3 kb of the rabbit smooth muscle myosin heavy chain promoter region. The deletion extends from intron 17 into the 3' region of the gene. (J:61119)
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Inheritance: | |
Not Specified |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lepr Mutation:
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27 strains or lines available |
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Notes |
Authors report variations in the obesity and diabetes phenotypes with the outbred mice (Him:Of1).
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| References |
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Original: |
J:61119
Reichart U et al.,
"Contrasting obesity phenotypes uncovered by partial leptin receptor gene deletion in transgenic mice."
Biochem Biophys Res Commun 2000 Mar 16;269(2):502-7
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All: |
1 reference(s)
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Analysis Tools
