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| Nomenclature |
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Symbol:
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E2f4tm1Lees
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Name:
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E2F transcription factor 4;
targeted mutation 1, Jacqueline A Lees
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MGI ID: |
MGI:1888952 |
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Synonyms: |
E2f4- |
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Gene:
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E2f4
Location:
Chr8:105297663-105305369 bp, + strand
Genetic Position: Chr8,
53.04 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:64193
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The gene was rendered inactive by the introduction of termination codons in all three open-reading frames after the fourth codon and the replacement with a PGK-neo cassette for the genomic sequences responsible for DNA binding and dimerization. (J:64193)
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Inheritance: | |
Semidominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:64193
Humbert PO et al.,
"E2F4 is essential for normal erythrocyte maturation and neonatal viability."
Mol Cell 2000 Aug;6(2):281-91
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All: |
10 reference(s)
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Analysis Tools
