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| Nomenclature |
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Symbol:
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Cdkn1atm1Led
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Name:
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cyclin-dependent kinase inhibitor 1A (P21);
targeted mutation 1, Philip Leder
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MGI ID: |
MGI:1888950 |
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Synonyms: |
p21-, p21Cip1, p21Cip1/Waf1 -, p21CIP1/WAF1 |
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Gene:
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Cdkn1a
Location:
Chr17:29090979-29100722 bp, + strand
Genetic Position: Chr17,
15.12 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:28420
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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A PGK-neomycin resistance cassette replaced a 3kb sequence containing exon 2. (J:28420)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:28420
Deng C et al.,
"Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control."
Cell 1995 Aug 25;82(4):675-84
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All: |
85 reference(s)
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Analysis Tools
