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| Nomenclature |
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Symbol:
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Gsk3btm1Jrw
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Name:
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glycogen synthase kinase 3 beta;
targeted mutation 1, James R Woodgett
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MGI ID: |
MGI:1888887 |
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Synonyms: |
gsk3b-, GSK-3beta- |
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Gene:
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Gsk3b
Location:
Chr16:38089001-38246084 bp, + strand
Genetic Position: Chr16,
26.54 cM, cytoband B4
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Increased bone mass in Gsk3btm1Jrw/Gsk3b+ mice
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:63274
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced an exon encoding the ATP-binding loop. Southern and Western blots of embryonic fibroblasts (E12.5) showed no detectable DNA and protein of the targeted gene, respectively. (J:63274)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gsk3b Mutation:
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86 strains or lines available |
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| References |
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Original: |
J:63274
Hoeflich KP et al.,
"Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation [see comments]"
Nature 2000 Jul 6;406(6791):86-90
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All: |
22 reference(s)
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Analysis Tools
