|
|
| Nomenclature |
|
Symbol:
|
Ndst1tm1Ekf
|
|
Name:
|
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1;
targeted mutation 1, Erik Forsberg
|
|
MGI ID: |
MGI:1888706 |
|
Synonyms: |
NDST-1- |
|
Gene:
|
Ndst1
Location:
Chr18:60685978-60713389 bp, - strand
Genetic Position: Chr18,
34.38 cM, cytoband D2
|
|
Newborn Ndst1tm1Ekf/Ndst1tm1Ekf mice display lung atelectasia
Show the 2 image(s) involving this allele.
|
 |
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:63996
|
|
Parent Cell Line:
| R1 (ES Cell) |
|
Strain of Origin:
|
(129X1/SvJ x 129S1/Sv)F1-Kitl+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: The functional mutant was generated by replacing the 3' portion of exon 1, which included the first 171 amino acids comprising both the cytoplasmic and trans-Golgi membrance domains, with a PGK-neo cassette. (J:63996)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Ndst1 Mutation:
|
2 strains or lines available |
|
| References |
|
Original: |
J:63996
Ringvall M et al.,
"Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1."
J Biol Chem 2000 Aug 25;275(34):25926-30
|
|
All: |
3 reference(s)
|
|
Analysis Tools
