|
|
| Nomenclature |
|
Symbol:
|
Tgfb2tm1Doe
|
|
Name:
|
transforming growth factor, beta 2;
targeted mutation 1, Thomas Doetschman
|
|
MGI ID: |
MGI:1888389 |
|
Synonyms: |
TGBbeta2-, Tgfb2-, TGF-beta2- |
|
Gene:
|
Tgfb2
Location:
Chr1:186623186-186705992 bp, - strand
Genetic Position: Chr1,
89.95 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:41682
|
|
Parent Cell Line:
| E14.1 (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: Exon 6 was disrupted by the insertion of a neomycin selection cassette. The insertion introduced stop codons in all three reading frames. RT-PCR analysis showed an absence of normal message in homozygous mutant mice. (J:41682)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
|
Notes |
Homozygotes exhibit a "Peters'-like" anomaly instead of an Axenfeld-Reiger's and Peter's anomaly (J:73681).
|
| References |
|
Original: |
J:41682
Sanford LP et al.,
"TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes."
Development 1997 Jul;124(13):2659-70
|
|
All: |
38 reference(s)
|
|
Analysis Tools
