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| Nomenclature |
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Symbol:
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Prlrtm1Cnp
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Name:
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prolactin receptor;
targeted mutation 1, Paul A Kelly
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MGI ID: |
MGI:1888377 |
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Synonyms: |
Prlr-, PRLRko |
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Gene:
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Prlr
Location:
Chr15:10177238-10349180 bp, + strand
Genetic Position: Chr15,
5.23 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:38093
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin cassette was inserted into exon 5, creating an in-frame stop codon. Northern, Western, and binding data all demonstrate the lack of a functional receptor in homozygous mutant animals. (J:38093)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:38093
Ormandy CJ et al.,
"Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse."
Genes Dev 1997 Jan 15;11(2):167-78
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All: |
44 reference(s)
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Analysis Tools
