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| Nomenclature |
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Symbol:
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Ntrk1tm1Bbd
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Name:
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neurotrophic tyrosine kinase, receptor, type 1;
targeted mutation 1, Mariano Barbacid
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MGI ID: |
MGI:1888374 |
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Synonyms: |
trkA-, trkAK-, trkTK |
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Gene:
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Ntrk1
Location:
Chr3:87778244-87795162 bp, - strand
Genetic Position: Chr3,
38.62 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:17194
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Sequences encoding 51 amino acids of the kinase catalytic domain were replaced with a neomycin cassette. RNase protection analysis on tissues isolated from homozygous mutant mice failed to identify any Ntrk1 transcripts. (J:17194)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:17194
Smeyne RJ et al.,
"Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene [see comments]"
Nature 1994 Mar 17;368(6468):246-9
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All: |
26 reference(s)
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Analysis Tools
