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| Nomenclature |
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Symbol:
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Juptm1Ruiz
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Name:
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junction plakoglobin;
targeted mutation 1, Patricia Ruiz
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MGI ID: |
MGI:1861958 |
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Synonyms: |
gamma-cat-, plakoglobin- |
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Gene:
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Jup
Location:
Chr11:100368958-100397763 bp, - strand
Genetic Position: Chr11,
63.47 cM
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Blood supply, particularly of liver and placenta, is reduced in Juptm1Ruiz/Juptm1Ruiz mice at E12
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:64280
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced a large part of exon 3, the following intronic sequences, and the 5' region of exon 4 of the gene, encoding amino acids 70 - 160. Northern and Western blots on E11.5 embryos showed no mRNA and protein, respectively, of the targeted gene. (J:64280)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:64280
Ruiz P et al.,
"Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart."
J Cell Biol 1996 Oct;135(1):215-25
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All: |
3 reference(s)
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Analysis Tools
