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| Nomenclature |
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Symbol:
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Htttm5Mem
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Name:
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huntingtin;
targeted mutation 5, Marcy E MacDonald
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MGI ID: |
MGI:1861935 |
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Synonyms: |
HdhQ111 |
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Gene:
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Htt
Location:
Chr5:34761740-34912534 bp, + strand
Genetic Position: Chr5,
17.92 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:52440
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: This allele carries 109 CAG repeat units, with 111 glutamines, in the first exon of the endogenous gene. It is a derivative of Htttm8 in which the neo cassette has been removed via cre-mediated recombination. (J:52440)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:52440
Wheeler VC et al.,
"Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse."
Hum Mol Genet 1999 Jan;8(1):115-22
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All: |
36 reference(s)
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Analysis Tools
