Gt(ROSA)26Sortm1Sor
Targeted Allele Detail
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| Nomenclature |
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Symbol:
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Gt(ROSA)26Sortm1Sor
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Name:
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gene trap ROSA 26, Philippe Soriano;
targeted mutation 1, Philippe Soriano
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MGI ID: |
MGI:1861932 |
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Synonyms: |
Gt(ROSA)26Sor, Gt(ROSA)26Sortm1(LacZ)Cos, Gtrosa26tm1Sor, Gtrosa26tm/Sor, loxP-Stop-loxP lacZ reporter, LSL-LacZ, R26-Cond-lacZ, R26-floxstop-lacZ, R26fslz, R26LacZ, R26-LNL-LacZ, R26R, R26R-lacZ, R26RLacZ, R26RZ, Rosa26 cre reporter, ROSA26fl, ROSA26-floxed Neo-LacZ, ROSA26-flox-STOP-flox-lacZ, Rosa26LacZ, ROSA26-LacZ, Rosa26-lacZ cre reporter, Rosa26-LacZloxP, ROSA26::LNL::LacZ, ROSA26-loxP, Rosa26loxP-STOP-lacZ, Rosa26-LoxSTOPLox-LacZ, Rosa26r-, ROSA26R, ROSA26Rflox, Rosa26RlacZ, Rosa26R-lacZ, Rosa26RLacZ, ROSA26Sortm1Sor, Rosa26stop-LacZ, ROSA26XneorXlacZ, Rosa2R, RosaLoxP, Rosa-LoxP-Stop-LoxP-LacZ, RS |
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Gene:
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Gt(ROSA)26Sor
Location:
Chr6:113067428-113077333 bp, - strand
Genetic Position: Chr6,
52.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:64292
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Parent Cell Line:
| AK7 (ES Cell) |
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Strain of Origin:
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129S4/SvJaeSor
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector was designed from the original gene trap strain, ROSA beta-geo26, to include a splice acceptor sequence (SA), a neo expression cassette flanked by loxP sites, a lacZ gene, and a polyadenylation (bpA) sequence inserted at a unique Xba1 site approximately 300-bp 5' of the original gene-trap integration site. In addition, a triple polyadenylation sequence was added to the 3' end of the neo expression cassette to prevent transcriptional read-through. Presence of the floxed neo cassette prevents lacZ expression. When crossed with a cre transgenic strain, lacZ is expressed in all cells/tissue where Cre is expressed. (J:64292, J:94076)
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Inheritance: | |
Not Specified |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:64292
Soriano P,
"Generalized lacZ expression with the ROSA26 Cre reporter strain [letter]"
Nat Genet 1999 Jan;21(1):70-1
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All: |
1534 reference(s)
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Analysis Tools
