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| Nomenclature |
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Symbol:
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Gad2tm1Bae
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Name:
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glutamic acid decarboxylase 2;
targeted mutation 1, Steinunn Baekkeskov
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MGI ID: |
MGI:1861928 |
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Synonyms: |
GAD 65 (-), GAD65 - |
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Gene:
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Gad2
Location:
Chr2:22622205-22693874 bp, + strand
Genetic Position: Chr2,
15.15 cM, cytoband A-B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:44638
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Parent Cell Line:
| JM-1 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance cassette was inserted into exon 1, downstream of the translation initiation start site. Western blot analysis on brain extracts from homozygous mice confirmed that no detectable protein is expressed from this allele. (J:44638)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Epilepsy (J:44638).
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| References |
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Original: |
J:44638
Kash SF et al.,
"Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase."
Proc Natl Acad Sci U S A 1997 Dec 9;94(25):14060-5
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All: |
10 reference(s)
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Analysis Tools
