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| Nomenclature |
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Symbol:
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Fcgr3tm1Sjv
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Name:
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Fc receptor, IgG, low affinity III;
targeted mutation 1, J Sjef Verbeek
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MGI ID: |
MGI:1861924 |
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Synonyms: |
FcgammaRIII- |
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Gene:
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Fcgr3
Location:
Chr1:171051174-171064935 bp, - strand
Genetic Position: Chr1,
78.8 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:35057
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A hygromycin selection cassette replaced a genomic fragment containing sequences encoding the ligand binding and part of the transmembrane domains. RT-PCR analysis on NK fractions of splenocytes derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. Flow cytometry analysis on NK cells, B lymphocytes, macrophages and neutrophils confirmed that no detectable cell surface protein was encoded by this allele. (J:35057)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:35057
Hazenbos WL et al.,
"Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice."
Immunity 1996 Aug;5(2):181-8
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All: |
83 reference(s)
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Analysis Tools
