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| Nomenclature |
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Symbol:
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Cd80tm1Shr
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Name:
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CD80 antigen;
targeted mutation 1, Arlene H Sharpe
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MGI ID: |
MGI:1861804 |
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Synonyms: |
B7-, B7-1-, B7.1, CD80- |
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Gene:
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Cd80
Location:
Chr16:38458933-38486933 bp, + strand
Genetic Position: Chr16,
26.86 cM, cytoband B5
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:74662
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced the exon encoding the IgV-like domain of the protein. RT-PCR analysis on RNA derived from spleen, thymus and LPS-stimulated B cells of homozygous mice demonstrated that no detectable transcript was produced from this allele. FACS analysis on B cells derived from homozygous mice confirmed that no functional protein was encoded by this allele. (J:74662)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:74662
Freeman GJ et al.,
"Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice."
Science 1993 Nov 5;262(5135):907-9
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All: |
114 reference(s)
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Analysis Tools
